Our Science

Our scientific endeavors at Calidi Biotherapeutics are driven by rigorous research, innovative approaches, and an unwavering commitment to combating solid tumors. We continuously explore the immense potential of immunotherapies, striving to redefine the boundaries of what's possible in cancer treatment.

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How It WorksNovel PlatformPublications

How the Calidi platforms work

What’s a Rich Text element?

The rich text element allows you to create and format headings, paragraphs, blockquotes, images, and video all in one place instead of having to add and format them individually. Just double-click and easily create content.

Static and dynamic content editing

A rich text element can be used with static or dynamic content. For static content, just drop it into any page and begin editing. For dynamic content, add a rich text field to any collection and then connect a rich text element to that field in the settings panel. Voila!

How to customize formatting for each rich text

Headings, paragraphs, blockquotes, figures, images, and figure captions can all be styled after a class is added to the rich text element using the "When inside of" nested selector system.

What’s a Rich Text element?

The rich text element allows you to create and format headings, paragraphs, blockquotes, images, and video all in one place instead of having to add and format them individually. Just double-click and easily create content.

Static and dynamic content editing

A rich text element can be used with static or dynamic content. For static content, just drop it into any page and begin editing. For dynamic content, add a rich text field to any collection and then connect a rich text element to that field in the settings panel. Voila!

How to customize formatting for each rich text

Headings, paragraphs, blockquotes, figures, images, and figure captions can all be styled after a class is added to the rich text element using the "When inside of" nested selector system.

What’s a Rich Text element?

The rich text element allows you to create and format headings, paragraphs, blockquotes, images, and video all in one place instead of having to add and format them individually. Just double-click and easily create content.

Static and dynamic content editing

A rich text element can be used with static or dynamic content. For static content, just drop it into any page and begin editing. For dynamic content, add a rich text field to any collection and then connect a rich text element to that field in the settings panel. Voila!

How to customize formatting for each rich text

Headings, paragraphs, blockquotes, figures, images, and figure captions can all be styled after a class is added to the rich text element using the "When inside of" nested selector system.

What’s a Rich Text element?

The rich text element allows you to create and format headings, paragraphs, blockquotes, images, and video all in one place instead of having to add and format them individually. Just double-click and easily create content.

Static and dynamic content editing

A rich text element can be used with static or dynamic content. For static content, just drop it into any page and begin editing. For dynamic content, add a rich text field to any collection and then connect a rich text element to that field in the settings panel. Voila!

How to customize formatting for each rich text

Headings, paragraphs, blockquotes, figures, images, and figure captions can all be styled after a class is added to the rich text element using the "When inside of" nested selector system.

Our pipeline is robust and ever-evolving, driven by our commitment to pioneering breakthroughs in cancer treatment.

Explore Pipeline

Something about the benefits of tech

Our top features are designed to provide you with a seamless experience and make your treatments as easy as possible.

Scientific Publications

Publication
event
NeuroNova & Supernova
Neuronova
SuperNova
RTNOVA

Transforming Tumor Immune Microenvironments with a Novel Systemic Enveloped Oncolytic Virotherapy Targeting All Tumor Sites

ASCO Annual Meeting 2024

June 1, 2024
Discover More
Read More
Publication
event
NeuroNova & Supernova
Neuronova
SuperNova
RTNOVA

Non-Clinical Evidence Supporting the Upcoming CLD-201 Clinical Trial: Cell-Based Oncolytic Virotherapy for Multiple Solid Tumors

ASCO Annual Meeting 2024

June 1, 2024
Discover More
Read More
Publication
event
NeuroNova & Supernova
Neuronova
SuperNova
RTNOVA

Phase 1 Study of Multiple Intracerebral Doses of a Neural Stem Cell-based Oncolytic Virotherapy for Treatment of Recurrent High-grade Gliomas

ASCO Annual Meeting 2024

June 1, 2024
Discover More
Read More
Publication
event
NeuroNova & Supernova
Neuronova
SuperNova
RTNOVA

Stem Cell Platforms for Enhanced Oncolytic Virotherapy

Festival of Biologics

April 16, 2024
Discover More
Read More
Publication
event
NeuroNova & Supernova
Neuronova
SuperNova
RTNOVA

Deciphering Anticancer Mechanisms of Oncolytic Virus-loaded Stem Cells

American Association for Cancer Research

April 9, 2024
Discover More
Read More
Publication
event
NeuroNova & Supernova
Neuronova
SuperNova
RTNOVA

Annual Meeting – SITC 2023 – Nov 1st to 5th 2023 in San Diego, CA, USA.

SUPERNOVA1 (SNV1), A NOVEL ONCOLYTIC-CELL BASED PLATFORM FOR CANCER THERAPY

November 3, 2023
Discover More
Read More
Publication
event
NeuroNova (NNV)
Neuronova
SuperNova

Phase 1 Study of Multiple Intracerebral Doses of a Neural Stem Cell-based Oncolytic Virotherapy for Treatment of Recurrent High-grade Gliomas

ASCO Annual Meeting 2024

June 1, 2024
Discover More
Read More
Publication
event
NeuroNova & SuperNova
Neuronova
SuperNova

Stem Cell Platforms for Enhanced Oncolytic Virotherapy

Festival of Biologics

April 16, 2024
Discover More
Read More
Publication
event
NeuroNova & SuperNova
Neuronova
SuperNova

Deciphering Anticancer Mechanisms of Oncolytic Virus-loaded Stem Cells

American Association for Cancer Research

April 9, 2024
Discover More
Read More
Publication
event
NeuroNova (NNV)
Neuronova
SuperNova

Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial

Lancet Oncology

August 22, 2021
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Publication
event
NeuroNova (NNV)
Neuronova
SuperNova

Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients

The Journal of Translational Medicine

May 18, 2020
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Publication
event
NeuroNova (NNV)
Neuronova
SuperNova

ASCO-SITC Clinical Immuno-Oncology Symposium February 6-8, 2020 Orlando, Florida.

Abstract 21: A cell-based platform to potentiate oncolytic virus therapies

February 6, 2020
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Press Release
event
SuperNova (SNV)
Neuronova
SuperNova

Calidi Biotherapeutics Announces Issuance of New U.S. Patent Covering Novel SuperNova Technology Platform

Calidi Biotherapeutics announced a new patent for its SuperNova technology, advancing its CLD-201 program into the clinic. The patent covers a unique cancer treatment combining stem cells and a smallpox vaccine. This strengthens Calidi’s position in developing innovative therapies for advanced solid tumors.

July 18, 2024
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Read More
Publication
event
SuperNova (SNV)
Neuronova
SuperNova

Non-Clinical Evidence Supporting the Upcoming CLD-201 Clinical Trial: Cell-Based Oncolytic Virotherapy for Multiple Solid Tumors

ASCO Annual Meeting 2024

June 1, 2024
Discover More
Read More
Publication
event
NeuroNova & SuperNova
Neuronova
SuperNova

Stem Cell Platforms for Enhanced Oncolytic Virotherapy

Festival of Biologics

April 16, 2024
Discover More
Read More
Publication
event
NeuroNova & SuperNova
Neuronova
SuperNova

Deciphering Anticancer Mechanisms of Oncolytic Virus-loaded Stem Cells

American Association for Cancer Research

April 9, 2024
Discover More
Read More
Publication
event
SuperNova (SNV)
Neuronova
SuperNova

Annual Meeting – SITC 2023 – Nov 1st to 5th 2023 in San Diego, CA, USA.

SUPERNOVA1 (SNV1), A NOVEL ONCOLYTIC-CELL BASED PLATFORM FOR CANCER THERAPY

November 3, 2023
Discover More
Read More
Publication
event
SuperNova (SNV)
Neuronova
SuperNova

Development of Allogeneic Stem Cell-Based Platform for Delivery and Potentiation of Oncolytic Virotherapy

National Center for Biotechnology Information

December 13, 2022
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Press Release
event
RTNova
Neuronova
SuperNova
RTNova

Calidi Biotherapeutics Collaborates with SIGA Technologies to Advance Calidi’s Revolutionary RTNova Virotherapy for Lung Cancer and Metastatic Solid Tumors

Calidi Biotherapeutics, Inc. (NYSE American: CLDI or “Calidi”), a clinical-stage biotechnology company developing a new generation of targeted antitumor virotherapies, today announced that it entered into a collaboration agreement with SIGA Technologies (Nasdaq: SIGA) in the first quarter of 2024, to support the development of Calidi’s systemic and targeted RTNova (CLD-400) virotherapy platform, which has the potential to provide a universal treatment for all tumor types.

June 10, 2024
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Read More
Publication
event
RTNova
Neuronova
SuperNova
RTNova

Transforming Tumor Immune Microenvironments with a Novel Systemic Enveloped Oncolytic Virotherapy Targeting All Tumor Sites

ASCO Annual Meeting 2024

June 1, 2024
Discover More
Read More

Calidi’s Contribution To The Treatment Of COVID-19

In A Short Time, The Novel Coronavirus Disease (COVID-19) Has Destructively Impacted Both The People Of The World And The Global Economy On A Historic Scale. As Of April 27th 2020, The World Health Organization (WHO) Reports Over 3,002,303 Confirmed Cases Globally, With The Worldwide Death Toll Rising Above 208,131.