Arming the Immune System to Kill Cancer

Our “off the shelf” stem cells deliver a viral payload that first kills cancer cells locally, and then supercharges the immune system to fight metastatic disease.

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We are developing a new generation of targeted immunotherapies that  attack solid tumors, and then teach the immune system to hunt down cancer cells elsewhere in the body.

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Where does the “Calidi” name come from?

The Calidi name is derived from the spanish “caliente” meaning heat, which signifies that Calidi’s cancer treatment transforms immunologically “cold” tumors, which the immune system is unaware of,  becoming “hot” following Calidi’s treatment. The immune system is thus engaged, and attacks the primary tumor and also distant metastases.

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Pioneering the Future

Calidi Biotherapeutics and City of Hope announce first patients dosed in a Phase 1 clinical trial, funded by the California Institute of Regenerative Medicine (CIRM), evaluating neural stem cells engineered to carry an oncolytic virus, CLD-101, in recurrent high-grade glioma patients.
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Our Partners
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Pioneering Progress

CEO of Calidi Biotherapeutics, Allan Camaisa, Visits Sully on Set of Big Biz TV to Discuss Recent Benchmarks in Advancing Pipeline for Cancer Cure.
Science

Discover the future of biotherapeutics with Calidi. Pioneering innovative solutions for solid tumors.

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Company Overview

Take a glimpse into Calidi's headquarters, based in San Diego, California, including members of our exceptional team. This video also highlights the latest updates on the company's Clinical Trials and path to becoming a publicly traded company.

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Investors

Join us on our journey towards creating a world free from the threat of cancer.

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Discover the latest from our facility

In the Pipeline: Next-Generation Therapies

Explore Calidi Biotherapeutics' robust and evolving lineup of innovative immunotherapies, each designed with precision and a vision for a healthier future.

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Meet the Visionaries Behind Calidi

Get to know the dedicated team at Calidi Biotherapeutics. A blend of experts and innovators, each member plays a pivotal role in our mission to redefine cancer treatment.

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Calidi Newsroom:
Stay Updated

Dive into the latest updates, research findings, and announcements from Calidi Biotherapeutics. Stay informed about our strides in the world of immunotherapy.

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Latest News

Press Release

Join Calidi Biotherapeutics’ Exclusive Live Investor Webinar and Q&A Session on April 24

SAN DIEGO, April 22, 2025 (GLOBE NEWSWIRE) -- Calidi Biotherapeutics Inc. (NYSE American: CLDI) (“Calidi”), a clinical-stage biotechnology company developing a new generation of targeted antitumor virotherapies, is pleased to invite investors to a webinar on April 24, 2025, at 4:15 p.m. ET.

April 22, 2025
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Press Release

Calidi Biotherapeutics Announces FDA Clearance of IND Application for CLD-201 in Solid Tumors

SAN DIEGO, April 17, 2025 (GLOBE NEWSWIRE) -- Calidi Biotherapeutics Inc. (NYSE American: CLDI) (“Calidi”), a clinical-stage biotechnology company pioneering targeted antitumor virotherapies, announced today that the U.S. Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application for CLD-201. This investigational, allogeneic stem cell-based immunotherapy is set to advance into clinical development for the treatment of solid tumors in adults, focusing on breast cancer, head & neck cancer and soft tissue sarcoma.

April 17, 2025
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Press Release

Calidi Biotherapeutics Announces Appointment of Guy Travis Clifton, MD as Chief Medical Officer, Consultant and Advisor

SAN DIEGO, April 10, 2025 (GLOBE NEWSWIRE) -- Calidi Biotherapeutics Inc. (NYSE American: CLDI) (“Calidi”), a clinical-stage biotechnology company developing a new generation of targeted antitumor virotherapies, today announced the appointment of Guy Travis Clifton, MD as Chief Medical Officer, Consultant and Advisor.

April 10, 2025
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A talented, seasoned group of world-class executives, doctors, and scientists producing revolutionary work.

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