Arming the Immune System to Kill Cancer

Our “off the shelf” stem cells deliver a viral payload that first kills cancer cells locally, and then supercharges the immune system to fight metastatic disease.

We are developing a new generation of targeted immunotherapies that  attack solid tumors, and then teach the immune system to hunt down cancer cells elsewhere in the body.

Where does the “Calidi” name come from?

The Calidi name is derived from the spanish “caliente” meaning heat, which signifies that Calidi’s cancer treatment transforms immunologically “cold” tumors, which the immune system is unaware of,  becoming “hot” following Calidi’s treatment. The immune system is thus engaged, and attacks the primary tumor and also distant metastases.

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In the Pipeline: Next-Generation Therapies

Explore Calidi Biotherapeutics' robust and evolving lineup of innovative immunotherapies, each designed with precision and a vision for a healthier future.

Meet the Visionaries Behind Calidi

Get to know the dedicated team at Calidi Biotherapeutics. A blend of experts and innovators, each member plays a pivotal role in our mission to redefine cancer treatment.

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Dive into the latest updates, research findings, and announcements from Calidi Biotherapeutics. Stay informed about our strides in the world of immunotherapy.

Latest News

Press Release

Calidi Biotherapeutics Debuts as a Publicly Traded Company Focused on Arming the Immune System to Fight Cancer with a New Generation of Targeted Immunotherapies

Calidi Biotherapeutics, Inc. (NYSE American: CLDI or “Calidi”), a clinical-stage biotechnology company developing a new generation of targeted immunotherapies, today announced the completion of its business combination with First Light Acquisition Group (FLAG), a special purpose acquisition company. The common stock and warrants of Calidi are expected to commence trading on the New York Stock Exchange American under the ticker symbols “CLDI” and “CLDI WS,” respectively, on September 13, 2023. The stockholders of FLAG approved the transaction on August 28, 2023, following approval by Calidi shareholders. Calidi’s existing management team, including Chief Executive Officer and Chairman Allan Camaisa, will lead the combined company.

September 13, 2023
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Press Release

Calidi Biotherapeutics to Present at Baird’s Global Healthcare Conference

Calidi Biotherapeutics, Inc., (approved for listing on NYSE American under “CLDI”), a clinical-stage biotechnology company that is developing a new generation of targeted immunotherapies, today announced that Allan Camaisa, CEO and Chairman of the Board, and Stephen Thesing, Chief Business Officer, will participate in a fireside chat at the upcoming Baird Global Healthcare Conference on Wednesday, September 13, 2023, at 7:55 a.m. ET.

September 12, 2023
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Press Release

Calidi Biotherapeutics and City of Hope announce first patient dosed in a Phase 1 clinical trial evaluating neural stem cells engineered to carry an oncolytic virus, CLD-101, in recurrent high-grade glioma patients

City of Hope, one of the largest cancer research and treatment organizations in the United States and a National Cancer Institute-designated comprehensive cancer Center, and Calidi Biotherapeutics Inc. (“Calidi”), a clinical-stage biotechnology company that is pioneering the development of allogeneic cell-based delivery of oncolytic viruses, today jointly announced that the first brain tumor patient was treated at City of Hope in a multicenter, Phase 1 clinical trial evaluating CLD-101, a leading-edge therapeutic candidate in Calidi’s NeuroNova program, comprising tumor-tropic neural stem cells (NSCs) that deliver an oncolytic adenovirus — CRAd-S-pk7 — selectively to tumor sites.

July 18, 2023
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